KEGG   Homo sapiens (human): 1075
Entry
1075              CDS       T01001                                 
Symbol
CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS
Name
(RefSeq) cathepsin C
  KO
K01275  cathepsin C [EC:3.4.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Disease
H00274  Papillon-Lefevre syndrome
H00425  Lysosomal cysteine protease deficiencies
H00696  Haim-Munk syndrome
H02050  Prepubertal periodontitis
Drug target
Brensocatib (DG03287): D12120 D12746
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1075 (CTSC)
  09143 Cell growth and death
   04210 Apoptosis
    1075 (CTSC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1075 (CTSC)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1075 (CTSC)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1075 (CTSC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.14  Dipeptidyl-peptidases and tripeptidyl-peptidases
    3.4.14.1  dipeptidyl-peptidase I
     1075 (CTSC)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1075 (CTSC)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1075 (CTSC)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1075 (CTSC)
SSDB
Motif
Pfam: Peptidase_C1 CathepsinC_exc Peptidase_C1_2
Other DBs
NCBI-GeneID: 1075
NCBI-ProteinID: NP_001805
OMIM: 602365
HGNC: 2528
Ensembl: ENSG00000109861
UniProt: P53634
Structure
Position
11:complement(88293592..88337736)
AA seq 463 aa
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
NT seq 1392 nt   +upstreamnt  +downstreamnt
atgggtgctgggccctccttgctgctcgccgccctcctgctgcttctctccggcgacggc
gccgtgcgctgcgacacacctgccaactgcacctatcttgacctgctgggcacctgggtc
ttccaggtgggctccagcggttcccagcgcgatgtcaactgctcggttatgggaccacaa
gaaaaaaaagtagtggtgtaccttcagaagctggatacagcatatgatgaccttggcaat
tctggccatttcaccatcatttacaaccaaggctttgagattgtgttgaatgactacaag
tggtttgccttttttaagtataaagaagagggcagcaaggtgaccacttactgcaacgag
acaatgactgggtgggtgcatgatgtgttgggccggaactgggcttgtttcaccggaaag
aaggtgggaactgcctctgagaatgtgtatgtcaacatagcacaccttaagaattctcag
gaaaagtattctaataggctctacaagtatgatcacaactttgtgaaagctatcaatgcc
attcagaagtcttggactgcaactacatacatggaatatgagactcttaccctgggagat
atgattaggagaagtggtggccacagtcgaaaaatcccaaggcccaaacctgcaccactg
actgctgaaatacagcaaaagattttgcatttgccaacatcttgggactggagaaatgtt
catggtatcaattttgtcagtcctgttcgaaaccaagcatcctgtggcagctgctactca
tttgcttctatgggtatgctagaagcgagaatccgtatactaaccaacaattctcagacc
ccaatcctaagccctcaggaggttgtgtcttgtagccagtatgctcaaggctgtgaaggc
ggcttcccataccttattgcaggaaagtacgcccaagattttgggctggtggaagaagct
tgcttcccctacacaggcactgattctccatgcaaaatgaaggaagactgctttcgttat
tactcctctgagtaccactatgtaggaggtttctatggaggctgcaatgaagccctgatg
aagcttgagttggtccatcatgggcccatggcagttgcttttgaagtatatgatgacttc
ctccactacaaaaaggggatctaccaccacactggtctaagagaccctttcaaccccttt
gagctgactaatcatgctgttctgcttgtgggctatggcactgactcagcctctgggatg
gattactggattgttaaaaacagctggggcaccggctggggtgagaatggctacttccgg
atccgcagaggaactgatgagtgtgcaattgagagcatagcagtggcagccacaccaatt
cctaaattgtag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (8)   
   KEGG DISEASE (4)   
   OMIM (4)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (60)   
   KEGG ORTHOLOGY (1)   
   RefGene (49)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (65)   
   RefSeq(nuc) (3)   
   GenBank (31)   
   EMBL (31)   
3D Structure (10)   
   PDB (10)   
Protein domain (3)   
   Pfam (3)   
All databases (162)   

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